Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 5 Articles
Survivin is an antiapoptotic protein expressed in tumor cells that correlates with\naggressiveness, prognosis and treatment. Objective: This review summarizes\nsignificance of survivin expression among different tumor types highlighting\nthe potential value of survivin as an important biomarker that may have an\nimpact on patient�s response to therapy with prognostic implications....
Tartar emetic (TE) was the first drug used to treat leishmaniasis.However, its use was discontinued due to high toxicity. Association\nof TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages\nand prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an\nAccelerated Blood Clearance (ABC) phenomenon, whereby recognition of liposomes by antibodies results in faster phagocytosis.\nThiswork evaluated the effect of TE administration on histopathological aspects and the effect of the ABC phenomenon on targeting\nand toxicity in mice. Our results show that treatment with free or liposomal TE had no effect on the erythrocyte count, on liver\nand spleen weight, and on hepatic, splenic, and cardiac histology in mice. Severe lesions were observed on the kidneys of animals\ntreated with a single dose of free TE. Treatment with TE in Lpeg after induction of ABC phenomenon caused a significant increase\nin Sb level in the liver without toxicity. Furthermore, mice treated with TE in liposomes showed normal renal histopathology. These\nresults suggest site-specific targeting of Sb to the liver after induction of ABC phenomenon with no toxicity to other organs....
Background : Cadmium is a heavy metal having toxic effects on most organ\nsystems of the body. Objectives : We aim to investigate the postulated protective\nproperties of olive oil in Cadmium-induced renal toxicity in mice by utilizing\nstandard biomarkers of renal toxicity, oxidative stress and histopathological\ncharacterization. Materials and Methods : Forty mice were randomly\ndivided into four groups of 10 mice each. Group 1 served as control group,\ngroup 2 was given Extra-virgin olive oil orally, group 3 was given Cadmium\nchloride and group 4 was given Cadmium chloride with Extra-virgin olive oil.\nAt the end of the experimental period, biochemical analysis histopathology of\nkidney was done. Results : The present study depicted that blood urea, serum\ncreatinine and the antioxidant markers (Superoxide dismutase, Glutathione peroxidase\nand Catalase) levels were significantly increased in group 3 compared\nto group 1 and 2. After administration of Extra-virgin olive oil with Cadmium\nin group 4, the levels of those markers significantly improved. Histopathology\nof the renal tissue showed severe damage of glomeruli, severely congested blood\nvessels and marked dilatation of Bowman�s capsule in group 3 with improvements\nof these changes in group 4. Conclusion : This study suggests that Extra-\nvirgin olive oil can be used as a cost effective safe anti-oxidative agent in the\nprevention of Cadmium toxicity....
A case of gouty tophus in the elbow of a 62-year-old male is presented. Fineneedle\naspiration (FNA) revealed the presence of acicular crystals, birefringent\nwhen viewed under polarized light as is typical for monosodium urate\ncrystals. Histological study of the removed lesion confirmed a typical gouty\ntophus. We briefly comment the main characteristics of this entity....
Background: Disturbances in the expressions of centrosomal proteins (CEPs) and regulatory proteins that\ncontrol G1-Sphase transition, like cyclins could participate in dysregulation of cell cycle control that has been\nincriminated in the pathogenesis of several malignancies. Centrosomal protein 55 (CEP55) has an important role\nin participation in the final stage of cell division, and cell cycle progression. CEP55 and Cyclin D1 expressions were\ndetected in several tumors but their prognostic and predictive roles in epithelial ovarian carcinoma (EOC) are still\nstudied.\nAim of the study: Explore tissue expressions of CEPP55 and Cyclin D1 in EOC correlating their expression with\npathological, clinical and prognostic parameters.\nMethods: CEP55 and Cyclin D1 expressions were evaluated in tissue biopsies that are retrieved from 60\ncases of epithelial ovarian carcinoma using immunohistochemistry, patients that were followed up for 3 years. The\nrelationship between their level of expressions and degree of differentiation, spread of the tumor, disease recurrence,\nresponse to therapy and survival were studied.\nResults: CEP55 expression in EOC was positively correlated with loss of differentiation of the tumor, presence of\nL.N (p<0.001), and distant metastases (p=0.012) and advanced stage of the tumor (p=0.007), cyclin D1 expression\nin EOC was positively correlated with loss of differentiation and advanced stage of the tumor, presence of L.N\n(p<0.001), and distant metastases (p=0.009). CEPP 55 and Cyclin D1 were positively correlated with each other.\nLow CEPP 55 and Cyclin D1 expressions were strongly correlated with optimal surgical eradication of the tumor,\nincreased 3-year overall survival (OS) and low incidence of tumor recurrence after therapy (P<0.001).\nConclusion: High levels of expression of CEPP 55 and Cyclin D1and are markers of poor prognosis in EOC\npatients....
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